Article
Association between functional genetic polymorphisms of human sulfotransferases 1A1 and 1A2.
Pharmacogenetics - 1 Mar 2000
Engelke C E, Meinl W, Boeing H, Glatt H
Abstract excerpt
Three human phenol sulfotransferases, provisionally named SULT1A1, 1A2 and 1A3, show 91-96% homology of their amino acid sequences and are encoded by neighbouring gene loci. Functional genetic polymorphisms are known for two of these sulfotransferases. In SULT1A1, a G to A transition leads to an Arg213 to His exchange and eliminates a Bsp143II restriction site. SULT1A1*His shows lower enzyme activity and...
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