Article
Phenol sulfotransferase SULT1A1*2 allele and enhanced risk of upper urinary tract urothelial cell carcinoma.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Nov 2007
Rouprêt Morgan, Cancel-Tassin Géraldine, Comperat Eva, Fromont Gaëlle, Sibony Mathilde, Molinié Vincent, Allory Yves, Triau Stéphane, Champigneulle Jacqueline, Gaffory Cécile, Larré Stéphane, de la Taille Alexandre, Richard François, Hamdy Freddie C, Cussenot Olivier
Abstract excerpt
Cytosolic sulfotransferases (SULT) are involved in detoxification pathways. A functional polymorphism in the SULT1A1 gene, leading to an Arg213His substitution (SULT1A1*2), is thought to confer susceptibility to various types of cancer. Upper urinary tract urothelial cell carcinomas (UUT-UCC) are rare (5% of all urothelial carcinomas). We genotyped 268 patients with UUT-UCC and 268 healthy controls matched for...
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