Article
Sulfotransferase (SULT) 1A1 polymorphism as a predisposition factor for lung cancer: a case-control analysis.
Lung cancer (Amsterdam, Netherlands) - 1 Feb 2002
Wang Yunfei, Spitz Margaret R, Tsou Amy Meng-Hsuan, Zhang Kerang, Makan Nimisha, Wu Xifeng
Abstract excerpt
SULT1A1 enzyme is a member of the sulfotransferase family that alters biological activities of numerous carcinogenic and mutagenic compounds through sulfation. A genetic polymorphism in the coding region of SULT1A1 gene has been associated with modulated enzyme activity. There is a G-->A nucleotide polymorphism in SULT1A1 gene that codes for an Arg-->His substitution, which results in decreased activity and...
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