Article
Phenol sulphotransferase SULT1A1*1 genotype is associated with reduced risk of colorectal cancer.
Pharmacogenetics - 1 Nov 2001
Bamber D E, Fryer A A, Strange R C, Elder J B, Deakin M, Rajagopal R, Fawole A, Gilissen R A, Campbell F C, Coughtrie M W
Abstract excerpt
Sulphation is an important detoxification pathway for numerous xenobiotics; however, it also plays an important role in the metabolism and bioactivation of many dietary and environmental mutagens, including heterocyclic amines implicated in the pathogenesis of colorectal and other cancers. A major sulphotransferase (SULT) enzyme in humans, SULT1A1, is polymorphic with the most common variant allele, SULT1A1*2,...
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