Article
Lipofectamine and related cationic lipids strongly improve adenoviral infection efficiency of primitive human hematopoietic cells.
Human gene therapy - 20 Nov 1998
Byk T, Haddada H, Vainchenker W, Louache F
Abstract excerpt
Adenoviral vectors have the potential to infect a large number of cell types including quiescent cells. Their use in hematopoietic cells is limited by the episomal form of their DNA, leading to transgene loss in the progeny cells. However, the use of this vector may be interesting for short-term...
Topics
- ADP-ribosyl Cyclase
- ADP-ribosyl Cyclase 1
- Adenoviridae
- Antigens, CD
- Antigens, CD34
- Antigens, Differentiation
- Cation Exchange Resins
- Cations
- Genes, Reporter
- Genetic Vectors
- Hematopoietic Stem Cells
- Humans
- Lac Operon
- Lipids
- Membrane Glycoproteins
- NAD+ Nucleosidase
- Phenotype
- Promoter Regions, Genetic