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Article

Gene transfer into murine hematopoietic stem cells with helper-free foamy virus vectors

1 Aug 2001

Abstract excerpt

Gene transfer into hematopoietic stem cells (HSCs) is an ideal treatment strategy for many genetic and hematologic diseases. However, progress has been limited by the low HSC transduction rates obtained with retroviral vectors based on murine leukemia viruses. This study examined the potential of vectors derived from the nonpathogenic human foamy virus (HFV) to transduce human CD34(+) cells and murine HSCs. More...

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Identifiers

PMID: 11468157
DOI: 10.1182/blood.v98.3.604

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Source receipt: pubmed, retrieved 7 Sept 2026.

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