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Transduction of human NOD/SCID-repopulating cells with both lymphoid and myeloid potential by foamy virus vectors

11 Jun 2002

Abstract excerpt

The efficiency of gene transfer into human hematopoietic stem cells by oncoretroviral vectors is too low for effective gene therapy of most hematologic diseases. Retroviral vectors based on the nonpathogenic foamy viruses (FV) are an alternative gene-transfer system. In this study, human umbilical cord blood CD34(+) cells were transduced with FV vectors by a single 10-h exposure to vector stocks and then injected...

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PMID: 12060773
DOI: 10.1073/pnas.122131099

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