Article
ATM mutations in female breast cancer patients predict for an increase in radiation-induced late effects.
International journal of radiation oncology, biology, physics - 1 Mar 2002
Iannuzzi Christopher M, Atencio David P, Green Sheryl, Stock Richard G, Rosenstein Barry S
Abstract excerpt
PURPOSE: Mutation of the ATM gene may be associated with enhanced radiosensitivity and increased radiation-induced morbidity. Denaturing high performance liquid chromatography (DHPLC) is a powerful new technique proven to be sensitive and accurate in the detection of missense mutations, as well as small deletions and insertions. We screened female breast cancer patients for evidence of ATM gene alterations using...
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