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Article

Enhanced radiation late effects and cellular radiation sensitivity in an ATM heterozygous breast cancer patient.

Radiation oncology investigations - 1 Jan 1999

Varghese S, Schmidt-Ullrich R K, Dritschilo A, Jung M

Abstract excerpt

We observed severe late effects in a patient treated with radiation therapy for breast cancer. Radiation survival studies of patient fibroblasts show an enhanced cellular radiation sensitivity (Do = 0.95 Gy). Genetic analysis reveals that the patient is heterozygous for a mutated ATM gene. Protein truncation test (PTT) and sequence analysis identified a truncation within the leucine zipper domain, corresponding...

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Source

Identifiers

PMID: 10492163
DOI: 10.1002/(SICI)1520-6823(1999)7:4<231::AID-ROI4>3.0.CO;2-S

Genes

ATM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Enhanced radiation late effects and cellular radiation sensitivity in an ATM heterozygous breast cancer patient.PMID 10492163Read ↗

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ATM mutations in female breast cancer patients predict for an increase in radiation-induced late effects.Semantic proximity Read ↗

Possession of ATM Sequence Variants as Predictor for Late Normal Tissue Responses in Breast Cancer Patients Treated With RadiotherapySemantic proximity Read ↗

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Genomic analysis of exceptional responders to radiotherapy reveals somatic mutations in ATM.Semantic proximity Read ↗

Cellular responses to radiation and risk of breast cancer.Semantic proximity Read ↗

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Influence of Nucleoshuttling of the ATM Protein in the Healthy Tissues Response to Radiation Therapy: Toward a Molecular Classification of Human RadiosensitivitySemantic proximity Read ↗

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