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Article

[Adjuvant irradiation in breast cancer patients with ATM gene heterozygous mutations: special focus on clinical efficacy/toxicity].

Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique - 1 Jun 2009

Chargari C, Kirova Y M, Even C, Monnier L, Dendale R, Campana F, Fourquet A

Abstract excerpt

Dysfunction of the ataxia telangiectasia mutated (ATM) gene has been related to defective cell cycle control and genomic instability due to the impaired repair of DNA double strand breaks. Although increased radiosensitivity in ATM heterozygous patients has been suggested in preclinical data, clinical implication of ATM variant remains debated. Despite frequent in vitro hypersensitivity in patients with severe...

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Source

Identifiers

PMID: 19162519
DOI: 10.1016/j.canrad.2008.11.010

Genes

ATM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

[Adjuvant irradiation in breast cancer patients with ATM gene heterozygous mutations: special focus on clinical efficacy/toxicity].PMID 19162519Read ↗

Clinical radiosensitivity in breast cancer patients carrying pathogenic ATM gene mutations: no observation of increased radiation-induced acute or late effectsSemantic proximity Read ↗

[DNA repair and tumour radiosensitivity: focus on ATM gene].Semantic proximity Read ↗

Impact of ATM rs1801516 on late skin reactions of radiotherapy for breast cancer: Evidences from a cohort study and a trial sequential meta-analysis.Semantic proximity Read ↗

Workshop on The Epidemiology of the ATM Gene: Impact on Breast Cancer Risk and Treatment, Present Status and Future Focus, Lillehammer, Norway, 29 June 2002.Semantic proximity Read ↗

Breast cancer in female carriers of ATM gene alterations: outcome of adjuvant radiotherapy.Semantic proximity Read ↗

Functional consequences of ATM sequence variants for chromosomal radiosensitivity.Semantic proximity Read ↗

Cellular responses to radiation and risk of breast cancer.Semantic proximity Read ↗

Radiation exposure, the ATM Gene, and contralateral breast cancer in the women's environmental cancer and radiation epidemiology study.Semantic proximity Read ↗

Risk of radiation-induced subcutaneous fibrosis in relation to single nucleotide polymorphisms in TGFB1, SOD2, XRCC1, XRCC3, APEX and ATM--a study based on DNA from formalin fixed paraffin embedded tissue samples.Semantic proximity Read ↗

Severe radiotoxicity in an allogeneic transplant recipient with a heterozygous ATM mutation.Semantic proximity Read ↗

ATM mutations in female breast cancer patients predict for an increase in radiation-induced late effects.Semantic proximity Read ↗

[Factors of late radiosensitivity of normal tissues].Semantic proximity Read ↗

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