Article
Absence of mutations in the ATM gene in breast cancer patients with severe responses to radiotherapy.
British journal of cancer - 1 Jan 1997
Appleby J M, Barber J B, Levine E, Varley J M, Taylor A M, Stankovic T, Heighway J, Warren C, Scott D
Abstract excerpt
The effectiveness of cancer radiotherapy is compromised by the small proportion (approximately 5%) of patients who sustain severe normal tissue damage after standard radiotherapy treatments. Predictive tests are required to identify these highly radiosensitive cases. Patients with the rare, recessively inherited, cancer-prone syndrome ataxia-telangiectasia (A-T) sustain extremely severe normal tissue necrosis...
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