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Article

Regulatory mechanisms at the mouse Igf2/H19 locus.

Molecular and cellular biology - 1 Dec 2001

Kaffer C R, Grinberg A, Pfeifer K

Abstract excerpt

The closely linked H19 and Igf2 genes show highly similar patterns of gene expression but are reciprocally imprinted. H19 is expressed almost exclusively from the maternally inherited chromosome, while Igf2 expression is mostly from the paternal chromosome. In humans, loss of imprinting at this locus is associated with tumors and with developmental disorders. Monoallelic expression at the imprinted Igf2/H19 locus...

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Identifiers

PMID: 11689707
DOI: 10.1128/MCB.21.23.8189-8196.2001
PMCID: PMC99983

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Regulatory mechanisms at the mouse Igf2/H19 locus.PMID 11689707Read ↗

H19 and Igf2 monoallelic expression is regulated in two distinct ways by a shared cis acting regulatory region upstream of H19.Semantic proximity Read ↗

The 5' flank of mouse H19 in an unusual chromatin conformation unidirectionally blocks enhancer-promoter communication.Semantic proximity Read ↗

A transcriptional insulator at the imprinted H19/Igf2 locus.Semantic proximity Read ↗

Epigenetic mechanisms underlying the imprinting of the mouse H19 gene.Semantic proximity Read ↗

A complex duplication created by gene targeting at the imprinted H19 locus results in two classes of methylation and correlated Igf2 expression phenotypes.Semantic proximity Read ↗

Mechanisms of Igf2/H19 Imprinting: DNA Methylation, Chromatin and Long-Distance Gene RegulationSemantic proximity Read ↗

The human and mouse H19 imprinting control regions harbor an evolutionarily conserved silencer element that functions on transgenes in Drosophila.Semantic proximity Read ↗

Tissue-specific insulator function at H19/Igf2 revealed by deletions at the imprinting control region.Semantic proximity Read ↗

Imprinting of Igf2 and H19 from a 130 kb YAC transgene.Semantic proximity Read ↗

Deletion of a silencer element disruptsH19imprinting independently of a DNA methylation epigenetic switchSemantic proximity Read ↗

TheH19Differentially Methylated Region Marks the Parental Origin of a Heterologous Locus without Gametic DNA MethylationSemantic proximity Read ↗

Epigenetic regulation of the <i>Igf2/H19</i> gene clusterSemantic proximity Read ↗

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