Article
H19 and Igf2 monoallelic expression is regulated in two distinct ways by a shared cis acting regulatory region upstream of H19.
Genes & development - 15 May 2000
Srivastava M, Hsieh S, Grinberg A, Williams-Simons L, Huang S P, Pfeifer K
Abstract excerpt
H19 and Igf2 are expressed in a monoallelic fashion from the maternal and paternal chromosomes, respectively. A region upstream of H19 has been shown to regulate such imprinted expression of both genes in cis. We have taken advantage of a loxP/cre recombinase-based strategy to delete this region...
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