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Mechanisms of Igf2/H19 Imprinting: DNA Methylation, Chromatin and Long-Distance Gene Regulation

1 May 2000

Abstract excerpt

The mouse Igf2 and H19 genes lie 70-kb apart on chromosome 7 and are reciprocally imprinted. Two regulatory regions are important for their parental allele-specific expression: a differentially methylated region (DMR) upstream of H19 and a set of tissue-specific enhancers downstream of H19. The enhancers specifically activate Igf2 on the paternal chromosome and H19 on the maternal chromosome. The interactions...

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PMID: 10788777
DOI: 10.1093/oxfordjournals.jbchem.a022661

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Mechanisms of Igf2/H19 Imprinting: DNA Methylation, Chromatin and Long-Distance Gene RegulationPMID 10788777Read ↗

Regulatory mechanisms at the mouse Igf2/H19 locus.Semantic proximity Read ↗

H19 and Igf2 monoallelic expression is regulated in two distinct ways by a shared cis acting regulatory region upstream of H19.Semantic proximity Read ↗

Epigenetic mechanisms underlying the imprinting of the mouse H19 gene.Semantic proximity Read ↗

The 5' flank of mouse H19 in an unusual chromatin conformation unidirectionally blocks enhancer-promoter communication.Semantic proximity Read ↗

The human and mouse H19 imprinting control regions harbor an evolutionarily conserved silencer element that functions on transgenes in Drosophila.Semantic proximity Read ↗

Epigenetic regulation of the <i>Igf2/H19</i> gene clusterSemantic proximity Read ↗

Igf2-H19, an imprinted tandem gene, is an important regulator of embryonic development, a guardian of proliferation of adult pluripotent stem cells, a regulator of longevity, and a ‘passkey’ to cancerogenesisSemantic proximity Read ↗

TheH19Differentially Methylated Region Marks the Parental Origin of a Heterologous Locus without Gametic DNA MethylationSemantic proximity Read ↗

Interaction between differentially methylated regions partitions the imprinted genes Igf2 and H19 into parent-specific chromatin loopsSemantic proximity Read ↗

Deletion of the H19 differentially methylated domain results in loss of imprinted expression of H19 and Igf2.Semantic proximity Read ↗

Establishment and maintenance of H19 imprinting in the germline and preimplantation embryo.Semantic proximity Read ↗

Developmental profile of H19 differentially methylated domain (DMD) deletion alleles reveals multiple roles of the DMD in regulating allelic expression and DNA methylation at the imprinted H19/Igf2 locus.Semantic proximity Read ↗

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