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Article

Analysis of sequence upstream of the endogenous H19 gene reveals elements both essential and dispensable for imprinting.

Molecular and cellular biology - 1 Apr 2002

Thorvaldsen Joanne L, Mann Mellissa R W, Nwoko Okechukwu, Duran Kristen L, Bartolomei Marisa S

Abstract excerpt

Imprinting of the linked and oppositely expressed mouse H19 and Igf2 genes requires a 2-kb differentially methylated domain (DMD) that is located 2 kb upstream of H19. This element is postulated to function as a methylation-sensitive insulator. Here we test whether an additional sequence 5' of H19 is required for H19 and Igf2 imprinting. Because repetitive elements have been suggested to be important for genomic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 11909940
DOI: 10.1128/MCB.22.8.2450-2462.2002
PMCID: PMC133727

Genes

DMD
CTCF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Analysis of sequence upstream of the endogenous H19 gene reveals elements both essential and dispensable for imprinting.PMID 11909940Read ↗

Developmental profile of H19 differentially methylated domain (DMD) deletion alleles reveals multiple roles of the DMD in regulating allelic expression and DNA methylation at the imprinted H19/Igf2 locus.Semantic proximity Read ↗

Deletion of the H19 differentially methylated domain results in loss of imprinted expression of H19 and Igf2.Semantic proximity Read ↗

CTCF binding sites promote transcription initiation and prevent DNA methylation on the maternal allele at the imprinted H19/Igf2 locus.Semantic proximity Read ↗

The human and mouse H19 imprinting control regions harbor an evolutionarily conserved silencer element that functions on transgenes in Drosophila.Semantic proximity Read ↗

Assessment of the CTCF Binding Sites and Repeat-Positions Upstream the Human <i>H19</i> GeneSemantic proximity Read ↗

Establishment and maintenance of H19 imprinting in the germline and preimplantation embryo.Semantic proximity Read ↗

H19 and Igf2 monoallelic expression is regulated in two distinct ways by a shared cis acting regulatory region upstream of H19.Semantic proximity Read ↗

A complex duplication created by gene targeting at the imprinted H19 locus results in two classes of methylation and correlated Igf2 expression phenotypes.Semantic proximity Read ↗

Mechanisms of Igf2/H19 Imprinting: DNA Methylation, Chromatin and Long-Distance Gene RegulationSemantic proximity Read ↗

Epigenetic mechanisms underlying the imprinting of the mouse H19 gene.Semantic proximity Read ↗

Tissue-specific insulator function at H19/Igf2 revealed by deletions at the imprinting control region.Semantic proximity Read ↗

Mouse/human sequence divergence in a region with a paternal-specific methylation imprint at the human H19 locus.Semantic proximity Read ↗

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