Article
Expression of adenylyl cyclase-4 (AC-4) in Y1 and forskolin-resistant adrenal cells.
Molecular and cellular endocrinology - 27 Feb 2004
Rui Xianliang, Al-Hakim Abdallah, Tsao Jennivine, Albert Paul R, Schimmer Bernard P
Abstract excerpt
Forskolin-resistant mutants of a mouse adrenocortical cell line present a complex phenotype in which adenylyl cyclase (AC) is resistant to activation by forskolin and by ACTH. ACTH-resistance results from a defect affecting transcription of the ACTH receptor and can be overcome by transfecting mutant cells with expression vectors encoding G beta/gamma. Forskolin-resistance results from an AC-4 deficiency. We now...
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