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Article

Decreased levels of guanyl nucleotide-binding regulatory protein alpha-subunits in Y1 adrenocortical tumor cell mutants resistant to forskolin.

Molecular endocrinology (Baltimore, Md.) - 1 Nov 1990

Schimmer B P, Tsao J

Abstract excerpt

Forskolin-resistant mutants arise from Y1 mouse adrenocortical tumor cells with a frequency indicative of a mutational event at a single genetic locus and exhibit adenylyl cyclases that are resistant to activation by forskolin, corticotropin, and guanyl-5'-yl-imidodiphosphate. This study examined the levels of guanyl nucleotide-binding regulatory protein subunits (G) in plasma membranes from the...

Topics

Adenylyl Cyclases
Adrenal Gland Neoplasms
Animals
Blotting, Western
Cell Membrane
Cholera Toxin
DNA Probes
Densitometry
Drug Resistance
GTP-Binding Proteins
Mice

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Phenotype

Poly(ADP-ribose) Polymerases

RNA

Tumor Cells, Cultured

Source

Identifiers

PMID: 1704099
DOI: 10.1210/mend-4-11-1698

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1704099-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Decreased levels of guanyl nucleotide-binding regulatory protein alpha-subunits in Y1 adrenocortical tumor cell mutants resistant to forskolin.PMID 1704099Read ↗

Mutations to forskolin resistance result in loss of adrenocorticotropin receptors and consequent reductions in levels of G protein alpha-subunits.Semantic proximity Read ↗

Analysis of the mutation to forskolin-resistance in Y1 adrenocortical tumor cells.Semantic proximity Read ↗

Forskolin-resistant Y1 adrenal cell mutants are deficient in adenylyl cyclase type 4.Semantic proximity Read ↗

Expression of adenylyl cyclase-4 (AC-4) in Y1 and forskolin-resistant adrenal cells.Semantic proximity Read ↗

Altered G protein activity in a desensitization-resistant mutant of the Y1 adrenocortical tumor cell line.Semantic proximity Read ↗

A role for guanyl nucleotide-binding regulatory protein beta- and gamma-subunits in the expression of the adrenocorticotropin receptor.Semantic proximity Read ↗

Molecular basis for the 3',5'-cyclic adenosine monophosphate resistance of Kin mutant Y1 adrenocortical tumor cells.Semantic proximity Read ↗

Receptor-G-protein coupling in desensitization-resistant mutant adrenal cells.Semantic proximity Read ↗

Regulation of adenylyl cyclase activity by beta-adrenergic agonists in a desensitization-resistant mutant cell line.Semantic proximity Read ↗

Adrenocorticotropin-resistant mutants of the Y1 adrenal cell line fail to express the adrenocorticotropin receptor.Semantic proximity Read ↗

Genetic selection of regulatory mutants of mammalian adenylyl cyclases.Semantic proximity Read ↗

Impaired steroidogenic factor 1 (NR5A1) activity in mutant Y1 mouse adrenocortical tumor cells.Semantic proximity Read ↗

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