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Article

Decreased levels of guanyl nucleotide-binding regulatory protein alpha-subunits in Y1 adrenocortical tumor cell mutants resistant to forskolin.

Molecular endocrinology (Baltimore, Md.) - 1 Nov 1990

Schimmer B P, Tsao J

Abstract excerpt

Forskolin-resistant mutants arise from Y1 mouse adrenocortical tumor cells with a frequency indicative of a mutational event at a single genetic locus and exhibit adenylyl cyclases that are resistant to activation by forskolin, corticotropin, and guanyl-5'-yl-imidodiphosphate. This study examined the levels of guanyl nucleotide-binding regulatory protein subunits (G) in plasma membranes from the...

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Identifiers

PMID: 1704099
DOI: 10.1210/mend-4-11-1698

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Decreased levels of guanyl nucleotide-binding regulatory protein alpha-subunits in Y1 adrenocortical tumor cell mutants resistant to forskolin.PMID 1704099Read ↗

Mutations to forskolin resistance result in loss of adrenocorticotropin receptors and consequent reductions in levels of G protein alpha-subunits.Semantic proximity Read ↗

Analysis of the mutation to forskolin-resistance in Y1 adrenocortical tumor cells.Semantic proximity Read ↗

Forskolin-resistant Y1 adrenal cell mutants are deficient in adenylyl cyclase type 4.Semantic proximity Read ↗

Expression of adenylyl cyclase-4 (AC-4) in Y1 and forskolin-resistant adrenal cells.Semantic proximity Read ↗

Altered G protein activity in a desensitization-resistant mutant of the Y1 adrenocortical tumor cell line.Semantic proximity Read ↗

A role for guanyl nucleotide-binding regulatory protein beta- and gamma-subunits in the expression of the adrenocorticotropin receptor.Semantic proximity Read ↗

Molecular basis for the 3',5'-cyclic adenosine monophosphate resistance of Kin mutant Y1 adrenocortical tumor cells.Semantic proximity Read ↗

Receptor-G-protein coupling in desensitization-resistant mutant adrenal cells.Semantic proximity Read ↗

Regulation of adenylyl cyclase activity by beta-adrenergic agonists in a desensitization-resistant mutant cell line.Semantic proximity Read ↗

Adrenocorticotropin-resistant mutants of the Y1 adrenal cell line fail to express the adrenocorticotropin receptor.Semantic proximity Read ↗

Genetic selection of regulatory mutants of mammalian adenylyl cyclases.Semantic proximity Read ↗

Impaired steroidogenic factor 1 (NR5A1) activity in mutant Y1 mouse adrenocortical tumor cells.Semantic proximity Read ↗

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