Relevance of pheno- and genotyping in clinical drug development.

Article

Relevance of pheno- and genotyping in clinical drug development.

International journal of clinical pharmacology and therapeutics - 1 Nov 1998

Zühlsdorf M T

Abstract excerpt

Individual variability in the plasma concentration of a xenobiotic is a considerable problem in the clinical use as well as in the clinical development of a new drug. In clinics altered drug response and drug toxicity are predominant findings. In clinical development (especially in the early phas...

Topics

Decision Trees
Drug Design
Drug Evaluation
Genotype
Humans
Pharmacogenetics
Pharmacokinetics
Pharmacology
Phenotype
Polymorphism, Genetic
Xenobiotics

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