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Article

Genetic variability in susceptibility and response to toxicants.

Toxicology letters - 31 Mar 2001

Ingelman-Sundberg M

Abstract excerpt

Xenobiotic metabolism is carried out by phase I and phase II enzymes which are to a large extent polymorphic. The majority of cytochrome P450 (CYP) enzymes involved in xenobiotic metabolism are polymorphic and inducible, resulting in abolished, quantitatively or qualitatively altered or enhanced drug metabolising activity. Stable duplication, multiduplication or amplification of active genes have been described....

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PMID: 11323184
DOI: 10.1016/s0378-4274(01)00278-8

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