Article
Pharmacogenetics and forensic toxicology.
Forensic science international - 15 Dec 2010
Musshoff Frank, Stamer Ulrike M, Madea Burkhard
Abstract excerpt
Large inter-individual variability in drug response and toxicity, as well as in drug concentrations after application of the same dosage, can be of genetic, physiological, pathophysiological, or environmental origin. Absorption, distribution and metabolism of a drug and interactions with its target often are determined by genetic differences. Pharmacokinetic and pharmacodynamic variations can appear at the level...
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