Pharmacogenetic phenotyping and genotyping. Present status and future potential.

Abstract excerpt

Enzymes that metabolise foreign compounds exhibit a large degree of interindividual variability in their levels of expression. In a number of instances this variability can be accounted for by null or variant alleles resulting from mutations in genes encoding these enzymes. Human variability in drug metabolism can be determined by biochemical and pharmacological assays. In cases where a genetic change has been...

Topics

• Biotransformation
• Cytochrome P-450 Enzyme System
• Enzymes
• Genotype
• Humans
• Phenotype
• Polymorphism, Genetic