Article
Phenotypic conversion from t(8;21) acute myeloid leukemia to MLL gene rearrangement-positive acute lymphoblastic leukemia.
Hematopathology and molecular hematology - 1 Jan 1998
Ohsaka A, Kato K, Hikiji K
Abstract excerpt
Phenotypic conversion from acute myeloid leukemia (AML) to acute lymphoblastic leukemia (ALL) is rare. A 38-year-old man was initially diagnosed as having AML (FAB-M2) associated with the t(8;21)(q22;q22) chromosomal abnormality. The blasts showed myeloperoxidase (MPO) activity and CD13 antigen e...
Topics
- Adult
- Chromosomes, Human, Pair 21
- Chromosomes, Human, Pair 8
- DNA-Binding Proteins
- Gene Rearrangement
- Histone-Lysine N-Methyltransferase
- Humans
- Leukemia, Myeloid, Acute
- Male
- Myeloid-Lymphoid Leukemia Protein
- Phenotype
- Precursor Cell Lymphoblastic Leukemia-Lymphoma
- Proto-Oncogenes
- Transcription Factors
- Translocation, Genetic