Article
Acute myeloid leukemia M2 and t(8;21)(q22;q22) with an unusual phenotype: myeloperoxidase (+), CD13 (-), CD14 (-), and CD33(-).
Annals of hematology - 1 May 1999
García Vela J A, Martin M, Delgado I, García Alonso L, Monteserin M C, Benito L, Somolinos N, Oña F
Abstract excerpt
Cases of myeloid surface antigen-negative acute myeloid leukemia (AML) are rare. We describe the morphological, cytochemical, immunologic, and cytogenetic features of two patients with AML with maturation (FAB M2) and the phenotype MPO+, CD13 (-), CD33(-), CD56(+). Cytogenetic studies demonstrated t(8;21)(q22;q22). These findings suggest an association between the lack of CD13 and CD33 in myeloperoxidase-positive...
Topics
- Adult
- Antibiotics, Antineoplastic
- Antigens, CD
- Antigens, Differentiation, Myelomonocytic
- Antimetabolites, Antineoplastic
- Bone Marrow Cells
- CD13 Antigens
- Cell Adhesion Molecules
- Chromosomes, Human, Pair 21
- Chromosomes, Human, Pair 8
- Cytarabine
- Female