Article
Cytogenetic analysis of acute myeloid leukemia with t(8;21) from a tertiary care center in India with correlation between clinicopathologic characteristics and molecular analysis.
Leukemia & lymphoma - 1 Jan 2012
Parihar Mayur, Kumar J Ashok, Sitaram Usha, Balasubramanian Poonkuzhali, Abraham Aby, Viswabandya Auro, George Biju, Mathews Vikram, Srivastava Alok, Srivastava Vivi M
Abstract excerpt
The t(8;21)(q22;q22) is the most common translocation in acute myeloid leukemia (AML). We describe the clinicopathologic and cytogenetic profile of 117 patients with t(8;21) AML. There were 76 males and 88 adults. The median age was 26 years. Most patients (80%) had AML M2. Dysplasia was present in 68% of patients and eosinophilia in 18%. Eight patients had fewer than 20% blasts. Additional chromosomal...
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