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Article

Transformation into acute myeloid leukemia with t(8;21)(q22;q22.1); RUNX1::RUNX1T1 from JAK2-mutated essential thrombocythemia: a case report.

Journal of medical case reports - 18 Aug 2024

Asou Chie, Sakamoto Tomoyuki, Suzuki Kodai, Okuda Itoko, Osaki Atsushi, Abe Ryohei, Ito Yoshihiro, Kakegawa Emi, Miyakawa Yoshitaka, Terui Yasuhito, Nakamura Yuichi

Abstract excerpt

BACKGROUND: Blast transformation is a rare but well-recognized event in Philadelphia-negative myeloproliferative neoplasms associated with a poor prognosis. Secondary acute myeloid leukemias evolving from myeloproliferative neoplasms are characterized by a unique set of cytogenetic and molecular features distinct from de novo disease. t(8;21) (q22;q22.1); RUNX1::RUNX1T1, one of the most frequent cytogenetic...

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Share to Chromosomes, Human, Pair 21
Share to Chromosomes, Human, Pair 8

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Core Binding Factor Alpha 2 Subunit

Share to Janus Kinase 2

Share to Leukemia, Myeloid, Acute

Share to RUNX1 Translocation Partner 1 Protein

Share to Thrombocythemia, Essential

Share to Translocation, Genetic

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Identifiers

PMID: 39154170
DOI: 10.1186/s13256-024-04691-0
PMCID: PMC11330597

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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