Acute myeloid leukemia with the t(8;21) translocation: clinical consequences and biological implications.

doi:10.1155/2011/104631

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Article

Acute myeloid leukemia with the t(8;21) translocation: clinical consequences and biological implications.

Journal of biomedicine & biotechnology - 1 Jan 2011

Reikvam Håkon, Hatfield Kimberley Joanne, Kittang Astrid Olsnes, Hovland Randi, Bruserud Øystein

Abstract excerpt

The t(8;21) abnormality occurs in a minority of acute myeloid leukemia (AML) patients. The translocation results in an in-frame fusion of two genes, resulting in a fusion protein of one N-terminal domain from the AML1 gene and four C-terminal domains from the ETO gene. This protein has multiple effects on the regulation of the proliferation, the differentiation, and the viability of leukemic cells. The...

Topics

Genetic Predisposition to Disease
Humans
Leukemia, Myeloid, Acute
Polymorphism, Single Nucleotide
Prevalence
Translocation, Genetic

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Identifiers

PMID: 21629739
DOI: 10.1155/2011/104631
PMCID: PMC3100545

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