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Article

Acute myeloid leukemia with the t(8;21) translocation: clinical consequences and biological implications.

Journal of biomedicine & biotechnology - 1 Jan 2011

Reikvam Håkon, Hatfield Kimberley Joanne, Kittang Astrid Olsnes, Hovland Randi, Bruserud Øystein

Abstract excerpt

The t(8;21) abnormality occurs in a minority of acute myeloid leukemia (AML) patients. The translocation results in an in-frame fusion of two genes, resulting in a fusion protein of one N-terminal domain from the AML1 gene and four C-terminal domains from the ETO gene. This protein has multiple effects on the regulation of the proliferation, the differentiation, and the viability of leukemic cells. The...

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Identifiers

PMID: 21629739
DOI: 10.1155/2011/104631
PMCID: PMC3100545

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Source receipt: pubmed, retrieved 7 Sept 2026.

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