Article
Binding of secretory precursor polypeptides to a translocon subcomplex is regulated by BiP.
Cell - 10 Jan 1997
Lyman S K, Schekman R
Abstract excerpt
The translocation of a secretory precursor protein across the ER membrane comprises three phases: docking of the precursor at the membrane, insertion into the translocation pore, and exit from the pore into the ER lumen. We demonstrate that Sec62p, Sec71p and Sec72p form a translocon subcomplex that engages secretory precursors at the membrane site of the ER translocation machinery. Binding of a precursor to the...
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