Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Interaction between BiP and Sec63p is required for the completion of protein translocation into the ER of Saccharomyces cerevisiae.

The Journal of cell biology - 1 Dec 1995

Lyman S K, Schekman R

Abstract excerpt

To clarify the roles of Kar2p (BiP) and Sec63p in translocation across the ER membrane in Saccharomyces cerevisiae, we have utilized mutant alleles of the essential genes that encode these proteins: kar2-203 and sec63-1. Sanders et al. (Sanders, S. L., K. M. Whitfield, J. P. Vogel, M. D. Rose, an...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Binding Sites
Share to Fungal Proteins
Share to Heat-Shock Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Membrane Proteins

Share to Membrane Transport Proteins

Share to Mutation

Share to Saccharomyces cerevisiae

Share to Saccharomyces cerevisiae Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 8522580
DOI: 10.1083/jcb.131.5.1163
PMCID: PMC2120636

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-8522580-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Interaction between BiP and Sec63p is required for the completion of protein translocation into the ER of Saccharomyces cerevisiae.PMID 8522580Read ↗

Sec61p serves multiple roles in secretory precursor binding and translocation into the endoplasmic reticulum membrane.Semantic proximity Read ↗

Sec63p and Kar2p are required for the translocation of SRP-dependent precursors into the yeast endoplasmic reticulum in vivo.Semantic proximity Read ↗

Genetic interactions between KAR2 and SEC63, encoding eukaryotic homologues of DnaK and DnaJ in the endoplasmic reticulum.Semantic proximity Read ↗

ER membrane protein complex required for nuclear fusion.Semantic proximity Read ↗

Specific molecular chaperone interactions and an ATP-dependent conformational change are required during posttranslational protein translocation into the yeast ER.Semantic proximity Read ↗

The Brl domain in Sec63p is required for assembly of functional endoplasmic reticulum translocons.Semantic proximity Read ↗

The Sec63p J-domain is required for ERAD of soluble proteins in yeast.Semantic proximity Read ↗

J domain co-chaperone specificity defines the role of BiP during protein translocation.Semantic proximity Read ↗

Loss of BiP/GRP78 function blocks translocation of secretory proteins in yeast.Semantic proximity Read ↗

Suppression of a sec63 mutation identifies a novel component of the yeast endoplasmic reticulum translocation apparatus.Semantic proximity Read ↗

Nonlethal sec71-1 and sec72-1 mutations eliminate proteins associated with the Sec63p-BiP complex from S. cerevisiae.Semantic proximity Read ↗

Signal sequences specify the targeting route to the endoplasmic reticulum membrane.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.