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Article

Myeloid cell dynamics in bleomycin-induced pulmonary injury in mice; effects of anti-TNFα antibody.

Toxicology and applied pharmacology - 15 Apr 2021

Venosa Alessandro, Gow James G, Taylor Sheryse, Golden Thea N, Murray Alexa, Abramova Elena, Malaviya Rama, Laskin Debra L, Gow Andrew J

Abstract excerpt

Bleomycin is a cancer therapeutic known to cause lung injury which progresses to fibrosis. Evidence suggests that macrophages contribute to this pathological response. Tumor necrosis factor (TNF)α is a macrophage-derived pro-inflammatory cytokine implicated in lung injury. Herein, we investigated the role of TNFα in macrophage responses to bleomycin. Treatment of mice with bleomycin (3 U/kg, i.t.) caused...

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Identifiers

PMID: 33647319
DOI: 10.1016/j.taap.2021.115470
PMCID: PMC10157853

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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