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Article

Critical role of tumor necrosis factor receptor 1 in the pathogenesis of pulmonary emphysema in mice.

International journal of chronic obstructive pulmonary disease - 1 Jan 2016

Fujita Masaki, Ouchi Hiroshi, Ikegame Satoshi, Harada Eiji, Matsumoto Takemasa, Uchino Junji, Nakanishi Yoichi, Watanabe Kentaro

Abstract excerpt

COPD is a major cause of chronic morbidity and mortality throughout the world. Although tumor necrosis factor-α (TNF-α) has a critical role in the development of COPD, the role of different TNF receptors (TNFRs) in pulmonary emphysema has not been resolved. We aimed to clarify the role of TNFRs in the development of pulmonary emphysema. TNF-α transgenic mice, a murine model of COPD in which the mice spontaneously...

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Identifiers

PMID: 27555760
DOI: 10.2147/COPD.S108919
PMCID: PMC4968668

Genes

TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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