Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Reduction of arthritis and pneumonitis in motheaten mice by soluble tumor necrosis factor receptor.

Arthritis and rheumatism - 1 Jan 1998

Su X, Zhou T, Yang P, Edwards C K, Mountz J D

Abstract excerpt

OBJECTIVE: To determine the effects of anti-tumor necrosis factor (anti-TNF) therapy in the inflammatory and autoimmune disease in motheaten (me/me) mice, which exhibit a Fas apoptosis signaling defect. METHODS: Arthritis, pneumonitis, and mortality were analyzed in me/me mice treated with a novel, soluble, dimeric TNF receptor I (sTNFRI) molecule capable of high-affinity binding and neutralization of TNFalpha....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antigens, CD
Share to Apoptosis
Share to Carrier Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to TNF gene

Share to Mice, Inbred C3H

Share to Mice, Mutant Strains

Share to Mutation

Source

Identifiers

PMID: 9433879
DOI: 10.1002/1529-0131(199801)41:1<139::AID-ART17>3.0.CO;2-T

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Reduction of arthritis and pneumonitis in motheaten mice by soluble tumor necrosis factor receptor.PMID 9433879Read ↗

The intriguing biology of the tumour necrosis factor/tumour necrosis factor receptor superfamily: players, rules and the gamesSemantic proximity Read ↗

Treatment of arthritis by macrophage depletion and immunomodulation: Testing an apoptosis‐mediated therapy in a humanized death receptor mouse modelSemantic proximity Read ↗

TNF receptor family signaling in the development and functions of medullary thymic epithelial cellsSemantic proximity Read ↗

Targeting sTNF/TNFR1 Signaling as a New Therapeutic StrategySemantic proximity Read ↗

Targeting the TNF and TNFR superfamilies in autoimmune disease and cancerSemantic proximity Read ↗

The role of TNF/TNFR in organ-specific and systemic autoimmunity: implications for the design of optimized 'anti-TNF' therapies.Semantic proximity Read ↗

Janus Kinase Inhibitor Tofacitinib Shows Potent Efficacy in a Mouse Model of Autoimmune Lymphoproliferative Syndrome (ALPS).Semantic proximity Read ↗

TNF-related ligands and their receptors.Semantic proximity Read ↗

Both anti-TNF and CTLA4 Ig treatments attenuate the disease severity of staphylococcal dermatitis in mice.Semantic proximity Read ↗

Tumor necrosis factor receptor p55 and p75 deficiency protects mice from developing experimental autoimmune myasthenia gravis.Semantic proximity Read ↗

TNF and TNFR biology in health and disease.Semantic proximity Read ↗

Allergic lung inflammation is mediated by soluble tumor necrosis factor (TNF) and attenuated by dominant-negative TNF biologics.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.