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Article

Allergic lung inflammation is mediated by soluble tumor necrosis factor (TNF) and attenuated by dominant-negative TNF biologics.

American journal of respiratory cell and molecular biology - 1 Oct 2011

Maillet Isabelle, Schnyder-Candrian Silvia, Couillin Isabelle, Quesniaux Valerie F J, Erard Francois, Moser René, Fleury Sébastien, Kanda Akira, Dombrowicz David, Szymkowski David E, Ryffel Bernhard

Abstract excerpt

Tumor Necrosis Factor (TNF) is a pleiotropic cytokine consisting of soluble and transmembrane forms, with distinct roles in inflammation and immunity. TNF is an important factor in allergic airway inflammation. However, the disparate functions of soluble (sol) and transmembrane (tm) TNF in lung pathology are not well understood. Our aim was to assess the activities of solTNF and tmTNF in murine models of allergic...

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Identifiers

PMID: 21297077
DOI: 10.1165/rcmb.2010-0512OC

Genes

TNF
CCL11
CCL17
CCL5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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