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Article

Transcriptional mutagenesis and DNA strand asymmetrical mutations expressed in Escherichia coli under restrictive metabolic conditions.

Mutation research - 3 Dec 1998

Bockrath R, Li B H

Abstract excerpt

Mutagenesis by C-to-U events specifically in either DNA strand assayed with ung uvrA defective Escherichia coli on a metabolically restrictive medium produces more glutamine tRNA suppressor mutations from U occurring in the non-transcribed DNA strand than from U in the transcribed (template) DNA strand. This bias is the reverse of what might be expected from transcriptional mutagenesis (mutation expression...

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PMID: 9838189
DOI: 10.1016/s0027-5107(98)00201-2

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