Article
Phenotypic change caused by transcriptional bypass of uracil in nondividing cells.
Science (New York, N.Y.) - 2 Apr 1999
Viswanathan A, You H J, Doetsch P W
Abstract excerpt
Cytosine deamination to uracil occurs frequently in cellular DNA. In vitro, RNA polymerase efficiently inserts adenine opposite to uracil, resulting in G to A base substitutions. In vivo, uracil could potentially alter transcriptional fidelity, resulting in production of mutant proteins. This study demonstrates that in nondividing Escherichia coli cells, a DNA template base replaced with uracil in a stop codon in...
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