Specificity of mutations in the PMS2-deficient human tumor cell line HEC-1-A.

doi:10.1016/s0027-5107(98)00208-5

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Article

Specificity of mutations in the PMS2-deficient human tumor cell line HEC-1-A.

Mutation research - 3 Dec 1998

Kato T, Yatagai F, Glickman B W, Tachibana A, Ikenaga M

Abstract excerpt

The spectrum of mutations was determined at the hypoxanthine-guanine phosphoribosyltransferase (hprt) locus in the human uterine tumor cell line HEC-1-A which is defective in the mismatch repair gene hPMS2. The mutation frequency at the hprt locus in HEC-1-A was about two orders higher than that...

Topics

Adenosine Triphosphatases
Carcinoma
DNA Repair
DNA Repair Enzymes
DNA-Binding Proteins
Endometrial Neoplasms
Female
Humans
Hypoxanthine Phosphoribosyltransferase
Mismatch Repair Endonuclease PMS2
Mutation
Proteins
Tumor Cells, Cultured

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