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Article

Differences in the spectrum of spontaneous mutations in the hprt gene between tumor cells of the microsatellite mutator phenotype.

Mutation research - 1 May 1996

Malkhosyan S, McCarty A, Sawai H, Perucho M

Abstract excerpt

We have determined the frequency and spectrum of spontaneous mutations at the hprt locus in LoVo, HCT116, LS180 and DLD-1 colon carcinoma cell lines exhibiting microsatellite genetic instability. Each cell line has a different mutator gene. LoVo and HCT116 cells have mutated hMSH2 and hMLH1 genes...

Topics

Base Sequence
Colonic Neoplasms
Colorectal Neoplasms, Hereditary Nonpolyposis
DNA Primers
DNA, Satellite
Female
Humans
Hypoxanthine Phosphoribosyltransferase
Male
Microsatellite Repeats
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Phenotype

Tumor Cells, Cultured

Source

Identifiers

PMID: 8649458
DOI: 10.1016/s0921-8734(96)90007-7

Genes

DLD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8649458-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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