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Article

Mutation rate at the hprt locus in human cancer cell lines with specific mismatch repair-gene defects.

Carcinogenesis - 1 Jan 1997

Glaab W E, Tindall K R

Abstract excerpt

Spontaneous mutation rates at the hypoxanthine-guanine phosphoribosyl transferase (hprt) locus were measured in human cancer cell lines defective in the mismatch repair (MMR) genes hMLH1, hPMS2, or GTBP, as well as in a cell line carrying mutations in both hMLH1 and hPMS2. The mutation rate was determined by quantitating mutant frequency increases within a single culture as a function of cell division. These...

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Identifiers

PMID: 9054582
DOI: 10.1093/carcin/18.1.1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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