Article
Conserved elements containing NF-E2 and tandem GATA binding sites are required for erythroid-specific chromatin structure reorganization within the human beta-globin locus control region.
Nucleic acids research - 15 Dec 1998
Pomerantz O, Goodwin A J, Joyce T, Lowrey C H
Abstract excerpt
Proper expression of the genes of the human beta-globin gene locus requires the associated locus control region (LCR). Structurally, the LCR is defined by the presence of four domains of erythroid-specific chromatin structure. These domains, which have been characterized as DNase I hypersensitive...
Topics
- Base Sequence
- Chromatin
- Conserved Sequence
- DNA-Binding Proteins
- Erythrocytes
- Erythroid-Specific DNA-Binding Factors
- GATA2 Transcription Factor
- Globins
- Hemoglobins
- Humans
- Molecular Sequence Data
- Mutation
- NF-E2 Transcription Factor
- NF-E2 Transcription Factor, p45 Subunit