Article
CCR5 promoter polymorphism and HIV-1 disease progression. Multicenter AIDS Cohort Study (MACS).
Lancet (London, England) - 12 Sept 1998
McDermott D H, Zimmerman P A, Guignard F, Kleeberger C A, Leitman S F, Murphy P M
Abstract excerpt
BACKGROUND: The rate of progression to AIDS varies among individuals infected with HIV-1. Factors responsible include two inherited human alleles, CCR5 delta32 and CCR2-641, which alter the protein-coding regions for the HIV-1 coreceptors/chemokine receptors CCR5 and CCR2b. We tested the hypothes...
Topics
- Acquired Immunodeficiency Syndrome
- Alleles
- Base Sequence
- Cohort Studies
- DNA
- Disease Progression
- HIV-1
- Humans
- Male
- Molecular Sequence Data
- Polymerase Chain Reaction
- Polymorphism, Genetic
- Polymorphism, Restriction Fragment Length
- Promoter Regions, Genetic
- Receptors, CCR5
- Receptors, Chemokine