Haplotype analysis of the SDF-1 (CXCL12) gene in a longitudinal HIV-1/AIDS cohort study.

doi:10.1038/sj.gene.6364258

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Article

Haplotype analysis of the SDF-1 (CXCL12) gene in a longitudinal HIV-1/AIDS cohort study.

Genes and immunity - 1 Dec 2005

Modi W S, Scott K, Goedert J J, Vlahov D, Buchbinder S, Detels R, Donfield S, O'brien S J, Winkler C

Abstract excerpt

The stromal-derived factor-1 (SDF-1) chemokine gene encodes the only natural ligand for CXCR4, the coreceptor for the pathogenic X4 HIV-1 strains. A single-nucleotide polymorphism (SNP) in the 3' untranslated region (SDF1-3'A=rs1801157) of SDF-1 was reported to be protective against infection and progression in some, but not other, epidemiological studies. To identify additional alleles that may influence HIV-1...

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PMID: 16177829
DOI: 10.1038/sj.gene.6364258

Genes

CXCL12
CXCR4

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