Article
CCR5 promoter polymorphism determines macrophage CCR5 density and magnitude of HIV-1 propagation in vitro.
Clinical immunology (Orlando, Fla.) - 1 Sept 2003
Salkowitz Janelle R, Bruse Shannon E, Meyerson Howard, Valdez Hernan, Mosier Donald E, Harding Clifford V, Zimmerman Peter A, Lederman Michael M
Abstract excerpt
The common CCR5 promoter polymorphism at position -2459 (A/G) has been associated with differences in the rate of progression to AIDS, where HIV-1-infected individuals with the CCR5 -2459 G/G genotype exhibit slower disease progression than those with the A/A genotype. Mechanisms underlying the relationship between these polymorphisms and disease progression are not known. Here through in vitro infection of...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.