Article
Cell-specific roles of glucokinase in glucose homeostasis.
Recent progress in hormone research - 1 Jan 2001
Postic C, Shiota M, Magnuson M A
Abstract excerpt
Mutations in the glucokinase (GK) gene cause two different diseases of blood glucose regulation: maturity onset diabetes of the young, type 2 (MODY-2) and persistent hyperinsulinemic hypoglycemia of infancy (PHHI). To gain further understanding of the pathophysiology of these disorders, we have used both transgenic and gene-targeting strategies to explore the relationship between GK gene expression in specific...
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