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Article

Glucokinase, the pancreatic glucose sensor, is not the gut glucose sensor.

Diabetologia - 1 Jan 2009

Murphy R, Tura A, Clark P M, Holst J J, Mari A, Hattersley A T

Abstract excerpt

AIMS/HYPOTHESIS: The incretin hormones glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotrophic peptide (GIP) are released from intestinal endocrine cells in response to luminal glucose. Glucokinase is present in these cells and has been proposed as a glucose sensor. The physiological role of glucokinase can be tested using individuals with heterozygous glucokinase gene (GCK) mutations. If...

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Source

Identifiers

PMID: 18974968
DOI: 10.1007/s00125-008-1183-9

Genes

GCK
GIP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Glucokinase, the pancreatic glucose sensor, is not the gut glucose sensor.PMID 18974968Read ↗

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Glucokinase (GCK) and other susceptibility genes for beta-cell dysfunction: the candidate approach.Semantic proximity Read ↗

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