Article
Insulin secretory abnormalities in subjects with hyperglycemia due to glucokinase mutations.
The Journal of clinical investigation - 1 Mar 1994
Byrne M M, Sturis J, Clément K, Vionnet N, Pueyo M E, Stoffel M, Takeda J, Passa P, Cohen D, Bell G I
Abstract excerpt
Pancreatic beta-cell function was studied in six subjects with mutations in the enzyme glucokinase (GCK) who were found to have elevated fasting and postprandial glucose levels in comparison to six normoglycemic controls. Insulin secretion rates (ISRs) were estimated by deconvolution of peripheral C-peptide values using a two-compartment model and individual C-peptide kinetics obtained after bolus intravenous...
Topics
- Adolescent
- Adult
- C-Peptide
- Female
- Glucokinase
- Glucose
- Glucose Tolerance Test
- Humans
- Hyperglycemia
- Insulin
- Insulin Secretion
- Male