Article
Glucose modulation of ATP-sensitive K-currents in wild-type, homozygous and heterozygous glucokinase knock-out mice.
Diabetologia - 1 Jun 1998
Sakura H, Ashcroft S J, Terauchi Y, Kadowaki T, Ashcroft F M
Abstract excerpt
One type of maturity-onset diabetes of the young (MODY2) is caused by mutations in the glucokinase gene, a key glycolytic enzyme in the beta cell and liver. Glucose fails to stimulate insulin secretion in mice in which the glucokinase gene has been selectively knocked out in the beta cell. We tes...
Topics
- Adenosine Triphosphate
- Animals
- Animals, Newborn
- Diabetes Mellitus, Type 2
- Eukaryotic Cells
- Glucokinase
- Glucose
- Heterozygote
- Homozygote
- Hypoglycemic Agents
- Islets of Langerhans
- Keto Acids
- Membrane Potentials
- Mice
- Mice, Knockout
- Mutation
- Potassium Channels
- Tolbutamide