HLA-DM acts as a molecular chaperone and rescues empty HLA-DR molecules at lysosomal pH.

doi:10.1016/s1074-7613(00)80332-5

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Article

HLA-DM acts as a molecular chaperone and rescues empty HLA-DR molecules at lysosomal pH.

Immunity - 1 Mar 1997

Kropshofer H, Arndt S O, Moldenhauer G, Hämmerling G J, Vogt A B

Abstract excerpt

HLA-DM (DM) is a nonclassical MHC class II molecule that interacts with classical MHC II molecules in acidic compartments. During this association DM is supposed to catalyze the release of invariant chain (Ii)-derived CLIP peptides, as well as other peptides bound with low kinetic stability. Here...

Topics

Alleles
B-Lymphocytes
Biological Transport
Carrier Proteins
Cell Compartmentation
Cell Line, Transformed
HLA-D Antigens
HLA-DR Antigens
Histocompatibility Antigens Class II
Humans
Hydrogen-Ion Concentration
Lysosomes
Molecular Chaperones

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