Polymorphic structural features of modelled HLA-DQ molecules segregate according to susceptibility or resistance to IDDM.

doi:10.1007/BF00401756

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Article

Polymorphic structural features of modelled HLA-DQ molecules segregate according to susceptibility or resistance to IDDM.

Diabetologia - 1 Nov 1995

Routsias J, Papadopoulos G K

Abstract excerpt

The structural features of HLA-DQ alleles which are susceptible and resistant to insulin-dependent diabetes mellitus (IDDM) have been examined using a model of their three-dimensional structure obtained by energy minimisation, based on the published structure of HLA-DR1. The model shows DQ molecu...

Topics

Alleles
Amino Acid Sequence
Antigen Presentation
CD4 Antigens
Diabetes Mellitus, Type 1
Disease Susceptibility
HLA-DQ Antigens
Humans
Models, Chemical
Molecular Sequence Data
Oligopeptides
Polymorphism, Genetic
Protein Conformation

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