Article
Polymorphic structural features of modelled HLA-DQ molecules segregate according to susceptibility or resistance to IDDM.
Diabetologia - 1 Nov 1995
Routsias J, Papadopoulos G K
Abstract excerpt
The structural features of HLA-DQ alleles which are susceptible and resistant to insulin-dependent diabetes mellitus (IDDM) have been examined using a model of their three-dimensional structure obtained by energy minimisation, based on the published structure of HLA-DR1. The model shows DQ molecules to have an overall shape nearly identical to that of DR molecules, but with significant differences in the fine...
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