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Article

Differences in self-peptide binding between T1D-related susceptible and protective DR4 subtypes.

Journal of autoimmunity - 1 Mar 2011

Ge Xinhui, James Eddie A, Reijonen Helena, Kwok William W

Abstract excerpt

HLA-DR0401, 0403 and 0405 are associated with variable T1D susceptibilities when linked with a common HLA-DQ8 (DQA1∗0301/DQB1∗0302). It is unknown how the modest differences within the peptide binding regions of DR4 subtypes lead to distinct autoimmune risks. Since all Class II HLA molecules share the same intracellular compartments during biosynthesis, it is possible that DQ and DR compete with one another to...

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Identifiers

PMID: 21257290
DOI: 10.1016/j.jaut.2010.12.004
PMCID: PMC3046295

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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