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Article

The generation of SDS-stable HLA DR dimers is independent of efficient peptide binding.

International immunology - 1 Mar 1996

Verreck F A, Vermeulen C, Poel A V, Jorritsma P, Amons R, Coligan J E, Drijfhout J W, Koning F

Abstract excerpt

MHC class II molecules can exist in two conformations which can be distinguished on the basis of their stability in SDS. The formation of SDS-stable dimers has been shown to correlate with persistent expression of antigen MHC class II-peptide complexes by murine antigen-presenting cells. HLA DR molecules contain either a Val or a Gly at position 86 of the beta chain, which is located in a conserved and prominent...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 8671626
DOI: 10.1093/intimm/8.3.397

Genes

SDS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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The generation of SDS-stable HLA DR dimers is independent of efficient peptide binding.PMID 8671626Read ↗

HLA-DR beta chain residue 86 controls DR alpha beta dimer stability.Semantic proximity Read ↗

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DM-mediated release of a naturally occurring invariant chain degradation intermediate from MHC class II molecules.Semantic proximity Read ↗

Beta 57-Asp plays an essential role in the unique SDS stability of HLA-DQA1*0102/DQB1*0602 alpha beta protein dimer, the class II MHC allele associated with protection from insulin-dependent diabetes mellitus.Semantic proximity Read ↗

Assembly and intracellular trafficking of HLA-B*3501 and HLA-B*3503.Semantic proximity Read ↗

Salt bridge residues between I-Ak dimer of dimers alpha-chains modulate antigen presentation.Semantic proximity Read ↗

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In vivo and in vitro formation and dissociation of HLA-DR complexes with invariant chain-derived peptides.Semantic proximity Read ↗

The set of naturally processed peptides displayed by DR molecules is tuned by polymorphism of residue 86.Semantic proximity Read ↗

Differential effect of polymorphism at HLA-DR1 beta-chain positions 85 and 86 on binding and recognition of DR1-restricted antigenic peptides.Semantic proximity Read ↗

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