Article
The generation of SDS-stable HLA DR dimers is independent of efficient peptide binding.
International immunology - 1 Mar 1996
Verreck F A, Vermeulen C, Poel A V, Jorritsma P, Amons R, Coligan J E, Drijfhout J W, Koning F
Abstract excerpt
MHC class II molecules can exist in two conformations which can be distinguished on the basis of their stability in SDS. The formation of SDS-stable dimers has been shown to correlate with persistent expression of antigen MHC class II-peptide complexes by murine antigen-presenting cells. HLA DR m...
Topics
- Amino Acid Sequence
- Antigen Presentation
- Cell Line, Transformed
- Genetic Variation
- Glycine
- HLA-DR Antigens
- Molecular Sequence Data
- Peptide Fragments
- Protein Binding
- Sodium Dodecyl Sulfate
- Valine