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Article

Differential stability of HLA-DR alleles independent of endogenous peptides.

Journal of immunology (Baltimore, Md. : 1950) - 15 Aug 1995

Devaux B, Wilson K J, Aguilar B, Jorgensen B, Rothbard J B

Abstract excerpt

Purified HLA DRB1*0101 was shown to be inherently more stable to dissociation than DRB1*0401. The residues responsible for the differential stability were defined by constructing hybrid molecules, which contained a small number of residues from DRB1*0101 substituted into the framework of DRB1*0401. One of the hybrid molecules, containing six substituted amino acids, was as stable as DRB1*0101, but exhibited the...

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Source

Identifiers

PMID: 7636243

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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